In the bustling world of biotechnology, a new frontier is emerging, one that could revolutionize how we approach health and wellness. Postbiotics, the non-living byproducts of probiotics, are stepping into the spotlight, and a recent perspective published in Frontiers in Nutrition is shedding light on how to quantify these powerful substances. The paper, led by Gabriel Vinderola from the Instituto de Lactología Industrial (CONICET-UNL), Facultad de Ingeniería Química, Universidad Nacional del Litoral, in Santa Fe, Argentina, offers a roadmap for the industry, addressing the challenges and opportunities in postbiotic quantification.
Imagine a world where the benefits of probiotics can be harnessed without the need for live microorganisms. This is the promise of postbiotics, and the market is taking notice. But how do we ensure these products are consistent and effective? That’s where quantification comes in.
The paper, discussed at the International Scientific Association for Probiotics and Prebiotics (ISAPP) 2024 meeting, brings together academic and industry experts to tackle this very question. “Postbiotics are complex mixtures,” explains Vinderola, “and full characterization of all components might not be feasible. But we need to confirm the identity and quantity of the original microorganisms and quantify some of its functional components.”
So, what’s the best way to do this? The paper suggests a toolbox of methods, including flow cytometry and quantitative polymerase chain reaction (qPCR). These techniques can help identify and quantify the microbial components of postbiotics, ensuring consistency and reproducibility. But here’s the twist: there’s no one-size-fits-all solution. The method chosen should be “fit for purpose,” depending on the complexity and type of microorganisms used.
This perspective is not just about the science; it’s about the future of the industry. As postbiotics gain traction, so does the need for standardized quantification methods. This paper is a step towards that, offering a decision tree to guide the deliberation among different quantification methods.
But why should the energy sector care? Well, postbiotics could play a significant role in bioenergy production. Some postbiotics can enhance the efficiency of biofuel production from agricultural waste, turning trash into treasure. Moreover, the methods discussed in this paper could be adapted to quantify other microbial products used in bioenergy, such as enzymes and biofuels themselves.
The paper also acknowledges that technology is evolving, and so will the methods for postbiotic quantification. “Our intent is not to prescribe a rigid framework,” says Vinderola, “but rather to provide guiding principles on approaches to quantifying postbiotics.”
As we stand on the cusp of a postbiotic revolution, this perspective offers a beacon, guiding the industry towards a future where these powerful substances can be consistently and effectively quantified. The energy sector, in particular, stands to gain, with potential applications in bioenergy production. So, buckle up, because the future of postbiotics is here, and it’s looking bright.