In the vast and lucrative world of shrimp farming, a microscopic foe has been wreaking havoc for decades. White Spot Syndrome Virus (WSSV) has been causing severe economic losses to the global farmed shrimp trade, with its rapid spread facilitated by the globalization of live shrimp trade and waterborne transmission. A recent review published in the journal ‘Viruses’ sheds light on the biology, pathology, and control strategies of this devastating virus, offering hope for the future of sustainable shrimp aquaculture.
The review, led by Md. Iftehimul from the Department of Biotechnology at Bangladesh Agricultural University, delves into the intricate details of WSSV, a double-stranded DNA virus belonging to the *Nimaviridae* family. The virus employs advanced immune evasion strategies, leading to high mortality rates in shrimp populations. “Shrimp lack adaptive immunity and rely predominantly on innate immunity, which is often insufficient to mount an effective response against severe infections,” explains Iftehimul.
The economic impact of WSSV on the shrimp farming industry is staggering. The virus has spread across major shrimp-producing countries since its initial emergence, causing significant losses in production and revenue. Traditional disease control measures such as biosecurity, selective breeding, and immunostimulants have achieved only limited success, highlighting the urgent need for innovative solutions.
The review highlights the potential of new biotechnological tools in combating WSSV. RNA interference, CRISPR-Cas gene editing, and nanotechnology offer promising avenues for disease mitigation. Additionally, the development of DNA and RNA vaccines targeting WSSV structural proteins, such as VP28, holds significant promise for stimulating the shrimp immune system.
The research underscores the importance of a convergent approach to sustainable disease management in global shrimp aquaculture. “Interdisciplinarity plays a pivotal role in shaping the future of WSSV control,” says Iftehimul. This means bringing together experts from various fields, including biology, technology, and agriculture, to tackle the challenge from multiple angles.
The findings of this review could shape future developments in the field of shrimp farming, offering hope for a more resilient and sustainable industry. By leveraging advanced biotechnological tools and fostering interdisciplinary collaboration, the global shrimp farming community can better combat the threat posed by WSSV and secure the future of this vital industry.
As the world continues to grapple with the economic and environmental impacts of shrimp farming, the insights provided by this review offer a beacon of hope. The fight against WSSV is far from over, but with continued research and innovation, the future of shrimp aquaculture looks brighter than ever.

